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IMMUNOHISTOCHEMICAL STUDY ON THE POSTNATAL DEVELOPMENT OF DENTAL PULP INNERVATION IN RAT POSTERIOR TEETH

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±èµ¿±æ/Dong Gil Kim ±èÇöÁ¤/³²¼øÇö/¹è¿ëö/±è¿µÁø/Hyun Jung Kim/Soon Hyun Nam/Yong Chul Bae/Young Jin Kim

Abstract

°á·Ð
Ä¡¾ÆÀÇ ¹ßÀ° ¹× ¸ÍÃâ¿¡ µû¸¥ Ä¡¼ö³» ½Å°æÁö¹èÀÇ ¹ß´ÞÀ» °üÂûÇϱâ À§ÇÏ¿© Ãâ»ýÈÄ 1, 5, 10,
15, 20, 25, 35ÀÏ µÈ ÈòÁã ¹× ¼ºÀåÀÌ ¿Ï·áµÈ ÈòÁã °¢ 5¸¶¸®¾¿ ÃÑ 40¸¶¸®ÀÇ ÇÏ¾Ç ±¸Ä¡¸¦ ´ë»ó
À¸·Î ÇÏ¿´À¸¸ç, calcitonin gene-related peptide(CGRP) Ç×ü¸¦ ÀÌ¿ëÇÏ¿© ¸é¿ªÁ¶Á÷È­ÇÐÀûÀ¸
·Î °üÂûÇÑ °á°ú ´ÙÀ½°ú °°Àº °á·ÐÀ» ¾ò¾ú´Ù.
CGRP ¸é¿ª¹ÝÀÀ ½Å°æ¼¶À¯´Â ¿ÜÇüÀÌ °ÅÄ¥¸é¼­ ¿°ÁÖ¾Ë ¸ð¾çÀ» ³ªÅ¸³»¾úÀ¸¸ç Ä¡¼ö³» ½Å°æ¼¶
À¯ÀÇ ÁøÀÔÀº »ó¾ÆÁú Çü¼ºÀÌ ½ÃÀ۵Ǵ ½Ã±â¿´´Ù. Raschkow plexus´Â Ä¡±ÙÇü¼º½Ã±âºÎÅÍ ¹ß´Þ
ÇÏ¿© Ä¡¾Æ°¡ ±¸°­³»·Î ¸ÍÃâµÇ¸é¼­ º¸´Ù ¹ß´ÞµÇ¾ú´Ù. Á¶»ó¾Æ¼¼Æ÷ÃþÀ¸·Î ÁøÀÔÇÏ´Â ½Å°æ¼¶À¯µµ
Ä¡¾Æ°¡ ±¸°­³»·Î ¸ÍÃâÇϸ鼭 ¹Ðµµ°¡ ³ô¾ÆÁ³´Ù. ½Å°æÁö¹è ¹ß´ÞÀº ¿ª¿¬·É(chronological age)
º¸´Ù Ä¡¾Æ¿¬·É(dental age)¿¡ µû¸£´Â °ÍÀ¸·Î ³ªÅ¸³µ´Ù.
#ÃÊ·Ï#
The purpose of this study was to investigate the postnatal development of pulpal
innervation with the tooth development and eruption process in developing rat
mandibular molars(postnatal 1, 5, 10, 15, 20, 25, 35day-old and adult rats).
Immunohistochemical method was carried out for the detection of nerve fibers, using the
antibody against calcitonin gene-related peptide(CGRP). The results were as follows :
The feature of CGRP-IR nerve fibers were shown in a bead-like appearance. The time
of nerve entering into the dental papilla of tooth follicle began at the occured advanced
dentinogenesis. The development of Raschkow plexus began at the formative stage of
the roots and was accelerated at the stage of the crown emerged into the oral cavity.
The number of nerve fibers entering the odontoblastic layer increased with the tooth
eruption and mastication. The development of innervation was shown to be related with
the stage of the development of individual teeth rather than the chronological age of the
rat.

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